Leash Bio releases Minos preprint and open dataset
What happened
Leash Bio uses DNA-encoded library (DEL) technology, attaching dozens of barcodes to each molecule and removing proteins that bind DNA rather than the drug, yielding clean, reproducible high-throughput data. Its Hermes model, trained only on the company's own data, matches Boltz on public benchmarks, and the team also found that the model memorises protein "nicknames" rather than binding sites. According to a report dated 15 October 2026, the agentic scientific reasoning sandbox that was just getting started at the time of recording has grown into Minos, which can provide tens of thousands of "lab-in-the-loop" simulations, with the related preprint, blog and open dataset now released.
Written by AI from the reports · updated 1 d ago
Timeline
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- Latent SpaceLab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio
How Leash Bio tamed DELs, the assay that traumatizes everyone, and used the data to catch cheating models. And why that same data is perfect for AI agents learning to think like chemists.
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